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By Dr. Syeda Maliha, PharmD

Curist delivers FDA-approved medicines to your door at a fraction of the price of traditional brands. We hope everyone stays safe and healthy during this time.

What is Simethicone? How Does Simethicone Work?

Simethicone is a medicine that is used to relieve abdominal bloating (fullness), pressure, or discomfort associated with gas. Simethicone is FDA approved and simethicone over-the-counter is available without a doctor’s prescription. Simethicone mainly works by breaking up trapped gas bubbles in your stomach and intestines, and in turn provides relief from gas pain and other symptoms like discomfort and bloating.

How Fast Does Simethicone Work for Gas?

Simethicone is fast and effective for treating excess gas. Simethicone typically provides relief within just a few minutes. However, since everyone’s body is different, the time it takes for simethicone to work may differ from person to person and so may take up to 30 minutes to work fully. 

What Strengths Does Simethicone Come In? 

Simethicone comes in many different strengths and dosage forms. The oral liquid-filled simethicone softgels typically come in strengths of simethicone 125 mg, simethicone 180 mg, simethicone 250 mg or simethicone 500 mg. The liquid drops of simethicone come in 40 mg/0.6 mL for adults and 20 mg/0.3 mL for infants. Curist Gas Relief is available in simethicone 250 mg strength, at a fraction of the price of other brands.


Depending on the severity of your gas pain and symptoms, you may start off with low-dose oral simethicone capsules and increase the dose or frequency if symptoms persist. It is important to keep in mind that 500 mg of simethicone per 24 hours is the maximum. If your symptoms are not relieved from taking simethicone daily, reach out to your healthcare provider. 

What are the Side Effects of Simethicone?

Overall, simethicone is very well tolerated and has no major side effects.However, if you feel any side effects while taking this medication, reach out to your health care provider immediately.


Is Simethicone Available Over-The-Counter (OTC)?

Yes, simethicone is available over-the-counter, for instance at Curist. Over-the-counter simethicone comes in multiple strengths, including simethicone 125 mg, simethicone 180 mg, simethicone 250 mg, and simethicone 500 mg. Curist Gas Relief is available in simethicone 250 mg strength, at a fraction of the price of other brands.

What is the Maximum  Strength of Simethicone Over-The-Counter (OTC)?

The maximum strength of simethicone available over-the-counter is simethicone 500 mg. Keep in mind that simethicone 500 mg is also the maximum amount of simethicone you can take per day, so simethicone 500 mg should only be taken once per day. Alternatively, you can take simethicone 250 mg two times a day. 

What is the Pediatric Dosage of Simethicone? What is the Adult Dosage of Simethicone?

The strength and dosage form of simethicone is dependent on age.

 

Simethicone For Pediatrics: 

  • Less than 2 year-old: simethicone 20 mg up to four times daily as needed after meals and at bedtime. The maximum daily dose of simethicone is 240 mg.
  • 2 to 12 year-old: simethicone 40 mg up to four times daily as needed after meals and at bedtime. The maximum daily dose of simethicone is 480 mg.

Simethicone For Adults

  • Simethicone 40 mg to 125 mg can be taken up to four times a day, as needed after meals or at bedtime. 
  • Simethicone 250 mg can be taken up to two times per day, as needed after meals or at bedtime. 
  • You can also take a single daily dose, ranging from simethicone 160 mg to simethicone 500 mg, after meals or at bedtime. Remember that the maximum daily dose of simethicone is 500 mg.

What is the Difference between Simethicone 125 mg vs Simethicone 180 mg vs Simethicone 250 mg vs Simethicone 500 mg?

The main difference between simethicone 125 mg vs simethicone 180 mg vs simethicone 250 mg vs simethicone 500 mg is the amount of active ingredient, simethicone, contained in a single dose and therefore the extent of gas relief per dose. Higher strengths of simethicone may offer stronger gas relief compared to lower strengths when taken. Note that the maximum dosage of simethicone per day is 500 mg, so if you prefer to take a dose throughout the day (say after each meal), it would be better to take smaller doses more frequently throughout the day, than just one daily 500 mg dose.


If your symptoms persist despite using the maximum amount of simethicone per day (500 mg), make sure to consult your doctor or pharmacist.


Curist Gas Relief is available in simethicone 250 mg strength, at a fraction of the price of other brands.

How Much Simethicone Can I Take Daily? Is 500 mg of Simethicone Too Much?

The maximum amount of simethicone you can take per day over-the-counter is 500 mg. So if you feel like you need extra strength of simethicone to help relieve gas pain and bloating, taking 500 mg of simethicone is not considered “too much”. Do not exceed 500 mg of simethicone per 24 hours. 


Can I Take 250 mg of Simethicone?

Yes, absolutely! You can take 250 mg of simethicone over-the-counter, either one or two times per day. If you are uncertain if this is the right strength or medication for you, consult with your doctor or pharmacist first. Curist Gas Relief is available in simethicone 250 mg strength, at a fraction of the price of other brands.

Can I Take Simethicone 125 mg and 500 mg Together?

No, you cannot take simethicone 125 mg and 500 mg together. The most common dose of simethicone is 40 mg to 125 mg taken up to four times a day as needed after meals and at bedtime. You may also take a single dose of simethicone 160 mg up to 500 mg after meals or at bedtime. However, you should not take more than 500 mg of simethicone per day.

Does Simethicone Make Me Drowsy?

Simethicone should not make you drowsy. Simethicone is a fast acting agent for stomach discomfort and bloating due to gas. Since this medicine is not absorbed into your bloodstream, simethicone should not make you drowsy.

Is There a Prescription Strength of Simethicone?

There is no prescription strength of simethicone. Simethicone is an over-the-counter medication and it is available in various dosage forms (e.g. chewable tablets, softgels, or liquid). The oral liquid-filled capsules of simethicone typically come in strengths of simethicone 125 mg, simethicone 180 mg, simethicone 250 mg, and simethicone 500 mg. The most amount of simethicone you can take per day is 500 mg of simethicone, or up to two doses of simethicone 250 mg per day.


Curist Gas Relief is available in simethicone 250 mg strength, at a fraction of the price of other brands.

Simethicone & More from Curist


Simethicone at a More Affordable Price

Simethicone & More from Curist

This content is for informational use only and does not replace professional medical advice, diagnosis or treatment. It is not a substitute for and should not be relied upon for specific medical recommendations. Please talk with your doctor about any questions or concerns.